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Progesterone Therapy And Preterm Birth: More Evidence Helps Identify Women Who Can Benefit
Two major studies
published today in The New England Journal of Medicine can help doctors
better identify pregnant women at risk for preterm delivery who can benefit
from progesterone treatment, the March of Dimes Foundation said.
In one large multi-center trial led by Eduardo B. Fonseca, M.D., women
with short cervix (most of whom had no prior history of preterm birth) who
received progesterone suppository treatment between 24 and 34 weeks
gestation had a greatly reduced rate of preterm birth.
Another large multi-center trial led by Dwight J. Rouse, M.D., found
that weekly injections of 17P (17 alpha-hydroxyprogesterone caproate, a
derivative of progesterone) between 16 and 35 weeks gestation did not
reduce the rate of preterm birth among women carrying twins.
"Premature birth is a growing problem in the United States and a
leading killer of newborns," said Michael Katz, senior vice president for
Research and Global Programs of the March of Dimes. "With this new
information, physicians will have a better idea of how to identify those
women who are most likely to benefit from progesterone treatment from those
who are not."
Dr. Katz noted that pathways to preterm birth may differ substantially
between singleton and twin gestations. For example, progesterone may be
more effective against some pathway that does not involve the uterine over-
distention seen in twin pregnancy.
"We need more research into the underlying causes of prematurity to
help women with other risk factors," Dr. Katz said.
In previous studies (Meis et al., NEJM, 2003;348:2379-85; da Fonseca et
al., Am J Ob Gyny, 2003;188:419-24), the benefit of progesterone was seen
in women with singleton pregnancies and a documented history of a previous
spontaneous preterm birth. These study results led to a Committee Opinion
issued by the American College of Obstetricians and Gynecologists on the
use of progesterone therapy, published in the October 2003 issue of
Obstetrics & Gynecology.
The March of Dimes works to improve the health of babies by preventing
birth defects, premature birth and infant mortality. For more information,
visit http://www.marchofdimes.com or http://www.nacersano.org for Spanish language information.
March of Dimes Foundation
http://www.marchofdimes.com/ny
Progesteron ºi terapie Preterm nasterii: mai multe dovezi vã ajutã sã identificaþi femeile care pot beneficia - Progesterone Therapy And Preterm Birth: More Evidence Helps Identify Women Who Can Benefit - articole medicale engleza - startsanatate